RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) are chemical compounds and can be made by the body. "Nucleic acid medicines" use "nucleic acid," which means substances such as DNA and RNA that control genetic information, as medicines. Therefore, DNA/RNA medicines are nucleic acid medicines. This kind of medicine as the next-generation drug discovery technology with a completely different mechanism of action is different from traditional pharmaceutical products. Moreover, it features the ability to be manufactured easily at moderate-sized molecules and the potential to exhibit efficacy and safety that surpasses those of antibody medicines. CD BioSciences is an excellent service provider and committed to providing a full range of custom DNA/RNA drug research services with high quality and low cost. Our end-to-end DNA/RNA drug discovery and development services will help you optimize the nucleic acid drug properties, promoting their applications in the precise treatment of genetic diseases.
Fig.1 Unmodified cellular nucleic acids. (Yu, 2019)
Clinical Experiences with DNA/RNA Drugs (Nucleic Acids Drugs)
Based on structures, targets, and mechanisms of action of nucleic acid drugs, they can be divided into six categories listed Table 1
Table.1 Six categories of DNA/RNA.
| Category | Structure | Target | Mechanism |
| Antisense | Single-strand DNA/RNA |
|
|
| siRNA | Double-strand RNA (hair-pine type is single-strand) |
mRNA | Cleavage mRNA(RNA interference) |
| miRNA | Double-strand RNA (pre-miRNA is single-strand) |
mRNA | miRNA replacement(RNA interference) |
| Aptamer | Single-strand DNA/RNA | Protein(outside of cells) | Inhibits the physiological effect |
| Decoy | Double-strand DNA | Transcription factor | Inhibits transcription |
| CpG-oligo | Single-strand DNA | TLR9-receptor | Adjuvant |
Experiences with DNA/RNA (Nucleic Acid Medicine)
CD BioSciences' experienced scientist teams have researched nucleic acid medicines for many years. Our expertise for generating quality data makes us to keep close relationships with key opinion leaders and practitioners, which can mean superior results and reliable recruitment for your research studies:
Overall Clinical Trial Services
Your clinical trial needs the best minds from beginning to end. CD BioSciences is a company that partners with research scientists and professionals in the biomedical industry, providing high quality nucleic acids for the research, diagnostic and therapeutic industries. During the research processes, CD BioSciences follows GLP and GMP guidelines. While synthetising DNA or RNA oligonucleotides, we use the solid-phase synthesis that is employed in a majority of molecular biology applications such as PCR, real-time PCR, sequencing, site-directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays and various therapeutic applications.
Strengths
CD BioSciences has a wealth of expertise in DNA and RNA drugs through various oligonucleotide modifications and methods. Our excellent expert staff provides a variety of flexible and reliable solutions to improve the therapeutic effect of DNA and RNA medicines. If you are interested in our services above, please feel free to contact us for more details.
Reference:
1. Yu, A. M.; et al. RNA therapy: Are we using the right molecules? Pharmacology & therapeutics. 2019, 196: 91-104.